Description

6,8-Difluoro-3,4-Dihydro-2H-Chromen-4-Amine is a high-purity fluorinated chromane derivative, serving as a critical chiral building block and advanced pharmaceutical intermediate. Its value lies in enabling the synthesis of complex molecules with enhanced biological activity and metabolic stability, crucial for modern drug discovery programs. This compound is primarily needed by research institutions and pharmaceutical companies engaged in developing new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorinated scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel fluorinated drug candidates, including potential kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in the synthesis of advanced fluorinated molecules for crop protection agents, leveraging fluorine's ability to improve lipophilicity and target binding.
• Material Science Precursor: Serves as a building block for specialty chemicals and advanced materials, such as liquid crystals or organic electronic components.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore the impact of fluorine substitution on chromane-based pharmacophores.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke fluorinated compounds for client projects.
• Academic Research: Utilized in universities and research institutes for methodological development in asymmetric synthesis and fluorine chemistry.

Basic Information

Product Name	6,8-Difluoro-3,4-Dihydro-2H-Chromen-4-Amine
CAS No.	886762-80-7
Molecular Formula	C9H9F2NO
Molecular Weight	185.17 g/mol
Synonyms	4-Amino-6,8-difluoro-3,4-dihydro-2H-chromene; 6,8-Difluoro-3,4-dihydro-2H-1-benzopyran-4-amine; 4-Amino-6,8-difluorochroman; 2H-1-Benzopyran-4-amine, 6,8-difluoro-3,4-dihydro-; 6,8-Difluorochroman-4-amine; 4-Amino-6,8-difluoro-2H-chromene
EINECS	Contact for details

Quality Control

Our 6,8-Difluoro-3,4-Dihydro-2H-Chromen-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.