Description

1-Fmoc-3-Hydroxyazetidine is a high-purity, protected azetidine derivative of significant importance in advanced organic synthesis. This compound serves as a critical building block for the construction of novel pharmaceutical scaffolds and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and the development of peptide mimetics.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Peptidomimetics & PROTACs: Used to introduce constrained, heterocyclic motifs that mimic peptide backbones or serve as linkers in proteolysis-targeting chimeras (PROTACs).
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by providing a versatile, Fmoc-protected azetidine alcohol for parallel and combinatorial synthesis.
• Chemical Biology Probes: Incorporation into molecular probes and tool compounds for studying biological pathways and enzyme function.
• Agrochemical Synthesis: Potential intermediate in the development of novel herbicides or fungicides with unique modes of action.
• Material Science: Exploration as a monomer or cross-linker for specialty polymers with tailored properties.

Basic Information

Product Name	1-Fmoc-3-Hydroxyazetidine
CAS No.	886510-13-0
Molecular Formula	C₁₈H₁₇NO₃
Molecular Weight	295.33 g/mol
Synonyms	3-Hydroxyazetidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-hydroxyazetidine; 1-Fmoc-3-hydroxyazetidine; Fmoc-Azetidinol; 3-Hydroxy-1-azetidinecarboxylic acid 9-fluorenylmethyl ester; Azetidin-3-ol, 1-[[(9H-fluoren-9-ylmethoxy)carbonyl]-; 1-(Fmoc)-3-hydroxyazetidine
EINECS	Contact for details

Quality Control

Our 1-Fmoc-3-Hydroxyazetidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.