Description

1-Bromo-5-Difluoromethyl-2-Fluorobenzene is a high-purity, multi-functional fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique substitution pattern, which enables precise molecular modifications in the creation of complex chemical architectures. It is primarily utilized by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring specific fluorinated aromatic motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials used in displays and lighting.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Buchwald-Hartwig aminations.
• Functional Polymer Monomer: Employed in the development of specialty polymers with tailored thermal, chemical, or surface properties.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries.

Basic Information

Product Name	1-Bromo-5-Difluoromethyl-2-Fluorobenzene
CAS No.	886509-99-5
Molecular Formula	C7H4BrF3
Molecular Weight	225.01 g/mol
Synonyms	2-Bromo-4-(difluoromethyl)-1-fluorobenzene; 4-(Difluoromethyl)-2-fluoro-1-bromobenzene; 1-Fluoro-2-bromo-4-(difluoromethyl)benzene; 2-Fluoro-5-bromobenzylidene difluoride; 886509-99-5; Benzene, 1-bromo-5-(difluoromethyl)-2-fluoro-; 5-Bromo-2-fluoro-alpha,α-difluorotoluene
EINECS	Contact for details

Quality Control

Our 1-Bromo-5-Difluoromethyl-2-Fluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.