Description

5-Methyl-2-(trifluoromethyl)benzyl bromide is a versatile and high-value benzyl bromide derivative, distinguished by the presence of both a methyl and a trifluoromethyl group on the aromatic ring. This compound is a critical building block in advanced organic synthesis, prized for its ability to introduce a reactive benzyl moiety while offering unique steric and electronic properties from its substituents. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized phosphine ligands or organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of monomers or functional agents for advanced polymers, liquid crystals, or organic electronic materials.
• Chemical Biology Probes: Useful for the alkylation of biomolecules or the preparation of chemical probes for studying enzyme function and protein interactions.

Basic Information

Product Name	5-Methyl-2-(trifluoromethyl)benzyl bromide
CAS No.	886502-86-9
Molecular Formula	C9H8BrF3
Molecular Weight	253.06 g/mol
Synonyms	α-Bromo-2-trifluoromethyl-5-methyltoluene; 1-(Bromomethyl)-5-methyl-2-(trifluoromethyl)benzene; 2-(Trifluoromethyl)-5-methylbenzyl bromide; (5-Methyl-2-(trifluoromethyl)phenyl)methyl bromide; 5-Methyl-α,α,α-trifluoro-o-tolyl bromide
EINECS	Contact for details

Quality Control

Our 5-Methyl-2-(trifluoromethyl)benzyl bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.