Description

4-Nitrobenzyl Chloride is a versatile and reactive organic intermediate of significant importance in fine chemical synthesis. Its primary value lies in its role as a key building block for introducing the 4-nitrobenzyl protecting group, particularly for carboxylic acids and alcohols in complex molecule assembly. This compound is essential for research and production in the pharmaceutical and agrochemical industries, where it is used to create active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of various active pharmaceutical ingredients (APIs), including certain antibiotics and cardiovascular drugs.
• Peptide Synthesis: Used as a protecting group reagent for carboxylic acids (forming 4-nitrobenzyl esters) during solid-phase and solution-phase peptide synthesis.
• Agrochemical Production: Serves as a building block for manufacturing herbicides, fungicides, and other crop protection agents.
• Dye and Pigment Manufacturing: Acts as an intermediate in the production of certain azo dyes and other complex colorants.
• Polymer Chemistry: Employed in the synthesis of specialty polymers and functional materials requiring nitrobenzyl moieties.
• Chemical Research: Utilized in organic synthesis laboratories for developing new methodologies and constructing complex molecular architectures.
• Cross-coupling Reactions: Serves as an electrophilic partner in palladium-catalyzed cross-coupling reactions to form biaryl structures.

Basic Information

Product Name	4-Nitrobenzyl Chloride
CAS No.	100-14-1
Molecular Formula	C7H6ClNO2
Molecular Weight	171.58 g/mol
Synonyms	p-Nitrobenzyl Chloride; 1-(Chloromethyl)-4-nitrobenzene; 4-Nitrobenzylchloride; (4-Nitrophenyl)methyl chloride; α-Chloro-4-nitrotoluene; p-Nitrobenzylchloride; 4-Nitrobenzyl Chloride; PNBC
EINECS	202-820-9

Quality Control

Our 4-Nitrobenzyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for our customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and light-sensitive nature, the container must be kept tightly sealed after opening to minimize exposure to moisture and light, which can degrade the product.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	69°C - 73°C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.