Description

2-Nitrobenzyl Bromide is a versatile and reactive aromatic building block, primarily valued for its role as a key intermediate in advanced organic synthesis. Its primary function is to introduce the 2-nitrobenzyl protecting group, which is crucial for the controlled synthesis of complex molecules. This compound is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where precise molecular construction is required.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring photolabile protecting groups.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, contributing to novel modes of action.
• Peptide & Nucleotide Chemistry: Functions as a photoremovable protecting group for carboxylic acids, amines, and phosphates in solid-phase and solution-phase synthesis.
• Material Science Research: Employed in the creation of photo-responsive polymers, surfaces, and smart materials for controlled release applications.
• Dye & Pigment Manufacturing: Acts as an intermediate in the production of specialized azo dyes and other nitro-aromatic colorants.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed reactions like Suzuki and Stille couplings for constructing biaryl systems.

Basic Information

Product Name	2-Nitrobenzyl Bromide
CAS No.	3958-60-9
Molecular Formula	C7H6BrNO2
Molecular Weight	216.03 g/mol
Synonyms	α-Bromo-2-nitrotoluene; 1-(Bromomethyl)-2-nitrobenzene; o-Nitrobenzyl Bromide; 2-Nitrobenzyl Bromide; (2-Nitrophenyl)methyl Bromide; Bromomethyl-2-nitrobenzene; NSC 404087
EINECS	223-552-1

Quality Control

Our 2-Nitrobenzyl Bromide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and light-sensitive nature, the container should be kept sealed under an inert atmosphere for long-term storage to prevent decomposition and moisture absorption.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.