Description

2'-Bromo-6'-Chloro-2,2,2-Trifluoro Acetophenone is a high-value, multi-halogenated acetophenone derivative that serves as a critical building block in advanced organic synthesis. This compound matters for its unique trifluoromethyl and halogen substitution pattern, which imparts desirable properties like metabolic stability and lipophilicity into target molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly those targeting protein kinases and other enzymes.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity.
• Material Science Precursor: Acts as a starting material for synthesizing specialized ligands, fluorinated liquid crystals, and advanced polymers.
• Chemical Biology Probes: Employed in creating tagged molecules for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP or research-grade conditions.

Basic Information

Product Name	2'-Bromo-6'-Chloro-2,2,2-Trifluoro Acetophenone
CAS No.	886502-80-3
Molecular Formula	C8H3BrClF3O
Molecular Weight	287.46 g/mol
Synonyms	1-(2-Bromo-6-chlorophenyl)-2,2,2-trifluoroethanone; 2-Bromo-6-chloro-α,α,α-trifluoroacetophenone; 2'-Bromo-6'-chloro-α,α,α-trifluoroacetophenone; (2-Bromo-6-chlorophenyl)(trifluoromethyl)methanone; 886502-80-3; 2-Bromo-6-chloro-2,2,2-trifluoroacetophenone; 2-Bromo-6-chloro-α,α,α-trifluoroacetophenone
EINECS	Contact for details

Quality Control

Our 2'-Bromo-6'-Chloro-2,2,2-Trifluoro Acetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports applications requiring research-grade to cGMP-compliant materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.