Description

5'-Iodo-2',2,2,2-Tetrafluoroacetophenone is a specialized fluorinated and iodinated aromatic ketone building block, offering unique reactivity for advanced chemical synthesis. Its molecular structure, featuring both an electron-withdrawing tetrafluoroacetyl group and a versatile iodine substituent, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in cross-coupling reactions and as a precursor to novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing fluorinated aromatic motifs which can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the fluorine and iodine atoms contribute to biological activity and environmental persistence profiles.
• Material Science Research: Acts as a monomer or precursor for synthesizing specialty polymers, liquid crystals, and organic electronic materials that require specific halogenated aromatic components.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira, Heck couplings), enabling the construction of complex biaryl and conjugated systems.
• Fluorination Chemistry: The tetrafluoroacetophenone moiety can be utilized to introduce perfluoroalkyl groups into target molecules or as a directing group in further functionalization.
• Chemical Research & Development: A valuable reagent for academic and industrial labs exploring new synthetic methodologies, particularly in organofluorine and organoiodine chemistry.

Basic Information

Product Name	5'-Iodo-2',2,2,2-Tetrafluoroacetophenone
CAS No.	886502-65-4
Molecular Formula	C8H3F4IO
Molecular Weight	317.96 g/mol
Synonyms	1-(2-Iodophenyl)-2,2,2-trifluoroethan-1-one; 2'-Iodo-α,α,α-trifluoroacetophenone; 2-Iodo-α,α,α-trifluoroacetophenone; 1-(2-Iodophenyl)-2,2,2-trifluoroethanone; 2-Iodophenyl trifluoromethyl ketone; (2-Iodophenyl)(trifluoromethyl)methanone; 886502-65-4
EINECS	Contact for details

Quality Control

Our 5'-Iodo-2',2,2,2-Tetrafluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the stringent requirements for research and process development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.