Description

2,3-Difluoro-6-Methoxybenzyl Bromide is a high-purity, multi-functional benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine and methoxy substituents, which are essential for modulating the electronic and steric properties of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in the development of fluorinated drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated active pharmaceutical ingredients (APIs), especially in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies.
• Cross-Coupling Reactions: The benzyl bromide moiety is reactive in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl structures.
• Functional Material Research: Employed in the development of novel polymers, ligands for catalysis, and specialty chemicals with tailored properties.

Basic Information

Product Name	2,3-Difluoro-6-Methoxybenzyl Bromide
CAS No.	886501-83-3
Molecular Formula	C8H7BrF2O
Molecular Weight	237.04 g/mol
Synonyms	1-(Bromomethyl)-2,3-difluoro-6-methoxybenzene; (2,3-Difluoro-6-methoxyphenyl)methyl Bromide; 2,3-Difluoro-6-methoxybenzylbromide; 2,3-Difluoro-6-methoxybenzyl Bromide; 2,3-Difluoro-6-methoxybenzyl bromide; 886501-83-3; 6-Methoxy-2,3-difluorobenzyl Bromide
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-6-Methoxybenzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.