Description

4'-Fluoro-3'-(trifluoromethoxy)acetophenone is a high-purity fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethoxy substituents, makes it a critical intermediate for introducing specific physicochemical properties into target molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its fluorinated motifs can enhance metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve lipophilicity and biological activity.
• Material Science Research: Serves as a precursor for specialty monomers and polymers, contributing to the development of advanced materials with specific optical or electronic properties.
• Liquid Crystal & OLED Development: Employed in the synthesis of fluorinated components for display and lighting technologies due to its ability to modify polarity and stability.
• Chemical Research & Process Development: Utilized in academic and industrial laboratories for method development and exploring new fluorination chemistry pathways.

Basic Information

Product Name	4'-Fluoro-3'-(trifluoromethoxy)acetophenone
CAS No.	886501-44-6
Molecular Formula	C9H6F4O2
Molecular Weight	222.14 g/mol
Synonyms	1-[4-Fluoro-3-(trifluoromethoxy)phenyl]ethanone; 4-Fluoro-3-(trifluoromethoxy)acetophenone; 1-(4-Fluoro-3-(trifluoromethoxyl)phenyl)ethan-1-one; 4'-Fluoro-3'-(trifluoromethoxy)acetophenone; 886501-44-6; Ethanone, 1-[4-fluoro-3-(trifluoromethoxy)phenyl]-; F3CO-Ph-COCH3 (4-F)
EINECS	Contact for details

Quality Control

Our 4'-Fluoro-3'-(trifluoromethoxy)acetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to consistent quality and traceability supports your R&D and scale-up processes with reliable material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.