Description

4-Chloro-3-(Trifluoromethoxy)Phenylacetonitrile is a high-value, multi-functional chemical intermediate characterized by its unique halogenated aromatic structure. This compound matters for its role as a versatile building block in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, crop protection, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the trifluoromethoxy group for enhanced biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the production of advanced electronic materials for displays and lighting, where its aromatic nitrile core contributes to molecular alignment and charge transport properties.
• Functional Polymer Monomer: Incorporated into specialty polymers to impart specific chemical resistance, thermal stability, or unique surface properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Sonogashira) and cyano-group transformations for constructing complex molecular architectures in medicinal chemistry.

Basic Information

Product Name	4-Chloro-3-(Trifluoromethoxy)Phenylacetonitrile
CAS No.	886500-97-6
Molecular Formula	C9H5ClF3NO
Molecular Weight	235.59 g/mol
Synonyms	2-(4-Chloro-3-(trifluoromethoxy)phenyl)acetonitrile; (4-Chloro-3-(trifluoromethoxy)phenyl)acetonitrile; 4-Chloro-3-(trifluoromethoxy)benzyl cyanide; α-(4-Chloro-3-(trifluoromethoxy)phenyl)acetonitrile; 886500-97-6; 4-Chloro-3-trifluoromethoxyphenylacetonitrile
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-(Trifluoromethoxy)Phenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with complete batch data are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.