Description

3,5-Difluoro-2-Methoxybenzyl Bromide is a high-value, multi-functional benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an indispensable reagent for introducing the difluoromethoxybenzyl moiety into target molecules, a key step in developing compounds with enhanced metabolic stability and bioavailability. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, including kinase inhibitors and other biologically active molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoromethoxy group can improve compound efficacy and environmental profile.
• Material Science Research: Serves as a precursor for synthesizing specialized monomers or ligands used in advanced polymers and functional materials.
• Chemical Biology & Proteomics: Employed in the design and synthesis of chemical probes and affinity tags for studying biological systems and protein function.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	3,5-Difluoro-2-Methoxybenzyl Bromide
CAS No.	886500-63-6
Molecular Formula	C8H7BrF2O
Molecular Weight	237.04 g/mol
Synonyms	1-(Bromomethyl)-3,5-difluoro-2-methoxybenzene; (3,5-Difluoro-2-methoxyphenyl)methyl Bromide; 2-Methoxy-3,5-difluorobenzyl Bromide; α-Bromo-3,5-difluoro-2-methoxytoluene; 886500-63-6; 3,5-Difluoro-2-methoxybenzylbromide
EINECS	Contact for details

Quality Control

Every batch of 3,5-Difluoro-2-Methoxybenzyl Bromide is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with the standards expected by the pharmaceutical and fine chemical industries, ensuring reliable performance in your critical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.