Description

2-Methoxy-4-(trifluoromethoxy)phenylacetonitrile is a high-value, multi-functional aromatic nitrile building block. This compound matters for its unique trifluoromethoxy-substituted phenyl core, which imparts desirable properties like enhanced metabolic stability and lipophilicity in advanced molecular design. It is primarily needed by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for synthesizing novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethoxy group.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies.
• Organic Electronics: Employed as a building block for electron-transport materials and organic semiconductors.
• Chemical Research: A versatile starting material for palladium-catalyzed cross-coupling reactions, cyano group transformations, and heterocycle formation.
• Fluorine Chemistry: An important compound for studying structure-activity relationships (SAR) in fluorinated aromatic systems.

Basic Information

Product Name	2-Methoxy-4-(trifluoromethoxy)phenylacetonitrile
CAS No.	886500-40-9
Molecular Formula	C10H8F3NO2
Molecular Weight	231.17 g/mol
Synonyms	4-(Trifluoromethoxy)-2-methoxyphenylacetonitrile; 2-Methoxy-4-(trifluoromethoxy)benzyl cyanide; (2-Methoxy-4-(trifluoromethoxy)phenyl)acetonitrile; α-Cyano-2-methoxy-4-(trifluoromethoxy)toluene; 886500-40-9; 2-Methoxy-α-((trifluoromethoxy)phenyl)acetonitrile; 4-(Trifluoromethoxy)-o-methoxyphenylacetonitrile
EINECS	Contact for details

Quality Control

Our 2-Methoxy-4-(trifluoromethoxy)phenylacetonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.