Description

2'-Methoxy-4'-(Trifluoromethoxy)Acetophenone is a specialized aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its unique trifluoromethoxy and methoxy substitution pattern, which imparts valuable electronic and steric properties to target molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, particularly where enhanced metabolic stability and lipophilicity are desired.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex drug candidates, especially in central nervous system (CNS) and anti-inflammatory research.
• Agrochemical Development: Used in constructing novel herbicides, fungicides, and insecticides where the trifluoromethoxy group improves biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor for advanced electronic materials requiring specific dipole moments and molecular geometry.
• Organic Synthesis Building Block: Employed in Friedel-Crafts acylation, Grignard reactions, and reductive amination to introduce functionalized acetophenone motifs.
• Chemical Research & Development: Utilized in academic and industrial labs for exploring new reaction methodologies and creating compound libraries for screening.

Basic Information

Product Name	2'-Methoxy-4'-(Trifluoromethoxy)Acetophenone
CAS No.	886500-08-9
Molecular Formula	C10H9F3O3
Molecular Weight	234.17 g/mol
Synonyms	1-[2-Methoxy-4-(trifluoromethoxy)phenyl]ethanone; 2-Methoxy-4-(trifluoromethoxy)acetophenone; 2'-Methoxy-4'-(trifluoromethoxy)acetophenone; 4-(Trifluoromethoxy)-2-methoxyacetophenone; 2-Methoxy-α,α,α-trifluoro-p-acetophenone; 886500-08-9; Ethanone, 1-[2-methoxy-4-(trifluoromethoxy)phenyl]-
EINECS	Contact for details

Quality Control

Our 2'-Methoxy-4'-(Trifluoromethoxy)Acetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.