Description

2-Fluoro-5-(trifluoromethoxy)benzamide is a high-purity fluorinated aromatic building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine and trifluoromethoxy groups can dramatically alter biological activity, metabolic stability, and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in areas like kinase inhibitors, CNS-active compounds, and anti-inflammatory agents.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy motifs enhance efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of advanced polymers and liquid crystals with specific optical or electronic properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, amide bond formations, and as a scaffold for constructing diverse heterocyclic compounds in medicinal chemistry.
• Fluorine Chemistry Studies: A valuable substrate for investigating structure-activity relationships (SAR) and the effects of polyfluorinated substituents on molecular behavior.

Basic Information

Product Name	2-Fluoro-5-(trifluoromethoxy)benzamide
CAS No.	886498-17-5
Molecular Formula	C8H5F4NO2
Molecular Weight	223.12 g/mol
Synonyms	2-Fluoro-5-(trifluoromethoxy)benzamide; Benzamide, 2-fluoro-5-(trifluoromethoxy)-; 5-(Trifluoromethoxy)-2-fluorobenzamide; 2-Fluoro-5-trifluoromethoxybenzamide; 886498-17-5; 2-Fluoro-α,α,α-trifluoro-p-anisamide; 2-Fluoro-5-(trifluoromethoxy)benzoic acid amide
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-(trifluoromethoxy)benzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.