Description

3'-Fluoro-5'-Methylacetophenone is a high-purity fluorinated aromatic ketone building block essential for advanced organic synthesis. Its unique structure, featuring both fluorine and methyl substituents, makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and functional materials. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and pesticides where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic and display materials, improving thermal and chemical stability.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Chemical Research & Development: A versatile reagent for exploring new fluorination methodologies and structure-activity relationships (SAR) in medicinal chemistry.
• Fine Chemical Production: Intermediate in the multi-step synthesis of complex flavors, fragrances, and dyes.

Basic Information

Product Name	3'-Fluoro-5'-Methylacetophenone
CAS No.	886497-73-0
Molecular Formula	C9H9FO
Molecular Weight	152.17 g/mol
Synonyms	1-(3-Fluoro-5-methylphenyl)ethanone; 3-Fluoro-5-methylacetophenone; 1-Acetyl-3-fluoro-5-methylbenzene; 3'-Fluoro-5'-methyl acetophenone; 3-Fluoro-5-methylphenyl methyl ketone; 886497-73-0; Ethanone, 1-(3-fluoro-5-methylphenyl)-
EINECS	Contact for details

Quality Control

Our 3'-Fluoro-5'-Methylacetophenone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliable batch-to-batch consistency for your development and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.