Description

3-Chloro-5-(Trifluoromethyl)Benzyl Bromide is a high-value halogenated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both chloro and trifluoromethyl substituents, makes it an essential precursor for introducing specific aromatic motifs into target molecules. This compound is particularly valuable for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl group.
• Liquid Crystal & OLED Materials: Serves as a precursor for synthesizing fluorinated aromatic compounds used in electronic display technologies.
• Polymer & Resin Modification: Employed to introduce halogenated benzyl groups into polymer chains to alter physical properties like thermal stability and solubility.
• Cross-Coupling Reactions: An effective electrophile in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Ligand & Catalyst Development: Used to create specialized phosphine or nitrogen-based ligands for asymmetric catalysis.

Basic Information

Product Name	3-Chloro-5-(Trifluoromethyl)Benzyl Bromide
CAS No.	886496-91-9
Molecular Formula	C8H5BrClF3
Molecular Weight	273.48 g/mol
Synonyms	1-(Bromomethyl)-3-chloro-5-(trifluoromethyl)benzene; α-Bromo-3-chloro-5-(trifluoromethyl)toluene; (3-Chloro-5-(trifluoromethyl)phenyl)methyl bromide; 3-Chloro-α-bromo-5-(trifluoromethyl)toluene; 3-Chloro-5-trifluoromethylbenzyl bromide; 3-Chloro-5-(trifluoromethyl)benzylbromide
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-(Trifluoromethyl)Benzyl Bromide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.