Description

2',3',4',5'-Tetramethyl-2,2,2-Trifluoroacetophenone is a specialized trifluoromethylated aromatic ketone, a key building block in advanced organic synthesis. Its value lies in the unique reactivity and electronic properties imparted by the trifluoroacetyl and tetramethylphenyl groups, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug molecules, especially those requiring trifluoromethyl groups for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of monomers and functional materials, such as liquid crystals or polymers with specific optical or electronic properties.
• Fluorine Chemistry Studies: A valuable reagent for academic and industrial research exploring new fluorination methodologies and the behavior of fluorinated aromatics.

Basic Information

Product Name	2',3',4',5'-Tetramethyl-2,2,2-Trifluoroacetophenone
CAS No.	886371-40-0
Molecular Formula	C13H15F3O
Molecular Weight	244.26 g/mol
Synonyms	1-(2,3,4,5-Tetramethylphenyl)-2,2,2-trifluoroethanone; 2,3,4,5-Tetramethyl-α,α,α-trifluoroacetophenone; 2,2,2-Trifluoro-1-(2,3,4,5-tetramethylphenyl)ethanone; α,α,α-Trifluoro-2',3',4',5'-tetramethylacetophenone; TFAP-TM; Trifluoroacetylpentamethylbenzene (common name); Pentamethyl Trifluoroacetophenone
EINECS	Contact for details

Quality Control

Our 2',3',4',5'-Tetramethyl-2,2,2-Trifluoroacetophenone is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.