Description

1-(5-Chloro-2-Methoxy-Phenyl)-2,2,2-Trifluoro-Ethylamine is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoroethylamine moiety attached to a substituted phenyl ring. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new therapeutic agents and crop protection products.

Application

• Pharmaceutical Intermediate: A key synthon for the research and production of new drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced herbicides and pesticides, leveraging the stability of the trifluoromethyl group.
• Ligand & Catalyst Development: Used in organometallic chemistry for creating specialized ligands in catalytic processes.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials with specific electronic properties.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	1-(5-Chloro-2-Methoxy-Phenyl)-2,2,2-Trifluoro-Ethylamine
CAS No.	886371-36-4
Molecular Formula	C9H9ClF3NO
Molecular Weight	239.62 g/mol
Synonyms	5-Chloro-2-methoxy-α-(trifluoromethyl)benzylamine; 1-(5-Chloro-2-methoxyphenyl)-2,2,2-trifluoroethanamine; α-(Trifluoromethyl)-5-chloro-2-methoxybenzylamine; 2,2,2-Trifluoro-1-(5-chloro-2-methoxyphenyl)ethanamine; 5-Chloro-α-(trifluoromethyl)-2-methoxybenzenemethanamine; 886371-36-4; Benzenemethanamine, 5-chloro-α-(trifluoromethyl)-2-methoxy-
EINECS	Contact for details

Quality Control

Our 1-(5-Chloro-2-Methoxy-Phenyl)-2,2,2-Trifluoro-Ethylamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.