Description

1-(5-Chloro-2-Methoxy-Phenyl)-2,2,2-Trifluoro-Ethanone is a high-purity trifluoromethyl ketone derivative, a key building block in advanced organic synthesis. Its unique structure, featuring both chloro and methoxy substituents on the aromatic ring, makes it a versatile and valuable intermediate for constructing complex molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to introduce the trifluoromethyl ketone pharmacophore, a moiety known to enhance metabolic stability, bioavailability, and binding affinity in active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and biological activity.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials with specific optical or electronic properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry for the creation of novel chiral ligands and catalysts used in asymmetric synthesis.
• Fluorine Chemistry Studies: An important reagent for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in medicinal and synthetic chemistry.

Basic Information

Product Name	1-(5-Chloro-2-Methoxy-Phenyl)-2,2,2-Trifluoro-Ethanone
CAS No.	886371-34-2
Molecular Formula	C9H6ClF3O2
Molecular Weight	238.59 g/mol
Synonyms	5'-Chloro-2'-methoxy-2,2,2-trifluoroacetophenone; 1-(5-Chloro-2-methoxyphenyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(5-chloro-2-methoxyphenyl)ethanone; 5-Chloro-2-methoxy-α,α,α-trifluoroacetophenone; (5-Chloro-2-methoxyphenyl)trifluoromethyl ketone; TFAP-CM Derivative; Trifluoromethyl Ketone Chloromethoxy Phenyl
EINECS	Contact for details

Quality Control

Our 1-(5-Chloro-2-Methoxy-Phenyl)-2,2,2-Trifluoro-Ethanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most sensitive synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.