Description

1-(2-Chloro-6-Methyl-Phenyl)-2,2,2-Trifluoro-Ethanone is a high-purity trifluoromethyl ketone derivative, a key building block in advanced organic synthesis. Its value lies in its unique chemical structure, which provides a reactive carbonyl center flanked by electron-withdrawing fluorine and chlorine substituents, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules containing trifluoromethyl groups, which are prevalent in modern drug discovery for their metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a key building block for developing advanced herbicides, fungicides, and insecticides, where the trifluoromethyl moiety enhances biological activity and environmental persistence.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and advanced organic electronic materials due to its ability to modify electronic properties and thermal stability.
• Fluorine Chemistry: An important reagent for introducing the trifluoroacetyl group into complex molecules, facilitating studies in fluorine chemistry and the creation of novel fluorinated compounds.
• Cross-Coupling Reactions: Acts as a substrate in various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures for diverse applications.

Basic Information

Product Name	1-(2-Chloro-6-Methyl-Phenyl)-2,2,2-Trifluoro-Ethanone
CAS No.	886371-29-5
Molecular Formula	C9H6ClF3O
Molecular Weight	222.59 g/mol
Synonyms	2-Chloro-6-methyl-α,α,α-trifluoroacetophenone; 2'-Chloro-6'-methyl-2,2,2-trifluoroacetophenone; 1-(2-Chloro-6-methylphenyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(2-chloro-6-methylphenyl)ethanone; α,α,α-Trifluoro-2-chloro-6-methylacetophenone; TFAP derivative; Trifluoroacetyl chloride methyl benzene derivative
EINECS	Contact for details

Quality Control

Our 1-(2-Chloro-6-Methyl-Phenyl)-2,2,2-Trifluoro-Ethanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring the material meets the stringent requirements for research and commercial synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.