Description

1-(2,5-Dichloro-Phenyl)-2,2,2-Trifluoro-Ethanone is a high-purity trifluoromethyl ketone derivative, serving as a critical advanced pharmaceutical intermediate and versatile building block in organic synthesis. Its unique structure, featuring both electron-withdrawing chlorine and trifluoromethyl groups, makes it an essential precursor for developing active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries to create novel compounds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly those requiring a trifluoromethyl ketone pharmacophore for enhanced binding and metabolic properties.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the dichloro-phenyl and trifluoroacetyl groups contribute to efficacy and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of novel organic electronic materials and liquid crystals due to its distinct electronic and steric profile.
• Fluorine Chemistry Studies: An important reagent for investigating the introduction and reactivity of fluorine-containing functional groups in aromatic systems.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules under cGMP conditions where applicable.

Basic Information

Item	Details
Product Name	1-(2,5-Dichloro-Phenyl)-2,2,2-Trifluoro-Ethanone
CAS No.	886371-22-8
Molecular Formula	C8H3Cl2F3O
Molecular Weight	243.01 g/mol
Synonyms	2',5'-Dichloro-2,2,2-trifluoroacetophenone; 2,5-Dichloro-α,α,α-trifluoroacetophenone; 1-(2,5-Dichlorophenyl)-2,2,2-trifluoroethanone; 2,5-Dichlorophenyl trifluoromethyl ketone; (2,5-Dichlorophenyl)(trifluoromethyl)methanone; TFAP-2,5-DCl; α,α,α-Trifluoro-2',5'-dichloroacetophenone
EINECS	Contact for details

Quality Control

Every batch of 1-(2,5-Dichloro-Phenyl)-2,2,2-Trifluoro-Ethanone is manufactured under a strict quality management system. We provide comprehensive analytical documentation to ensure traceability, purity, and consistency for your critical R&D and production processes. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for all shipments. Our quality protocols are designed to support development work that may scale to cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. This material should be stored separately from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.