Description

1-(4-Chloro-2-Fluoro-Phenyl)-2,2,2-Trifluoro-Ethanone is a high-purity fluorinated aromatic ketone building block. This compound is valued for its role as a key synthetic intermediate in the development of advanced active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily required by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with specific biological activity.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the manufacturing of advanced herbicides and pesticides, where the trifluoromethyl and halogenated phenyl groups contribute to enhanced efficacy and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of fluorinated polymers and advanced organic electronic materials due to its unique electronic properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines.

Basic Information

Product Name	1-(4-Chloro-2-Fluoro-Phenyl)-2,2,2-Trifluoro-Ethanone
CAS No.	886370-99-6
Molecular Formula	C8H3ClF4O
Molecular Weight	226.56 g/mol
Synonyms	4-Chloro-2-fluorobenzotrifluoride; 4'-Chloro-2'-fluoro-α,α,α-trifluoroacetophenone; 1-(4-Chloro-2-fluorophenyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(4-chloro-2-fluorophenyl)ethanone; 4-Chloro-2-fluoro-α,α,α-trifluoroacetophenone; p-Chloro-o-fluoro-α,α,α-trifluoroacetophenone; 886370-99-6 (CAS)
EINECS	Contact for details

Quality Control

Our 1-(4-Chloro-2-Fluoro-Phenyl)-2,2,2-Trifluoro-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment supports applications requiring high-purity intermediates for pharmaceutical and agrochemical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, reducing agents, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.