Description

1-(2-Chloro-4-Fluoro-Phenyl)-2,2,2-Trifluoro-Ethanone is a high-purity fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its unique structure, featuring both chloro and fluoro substituents on the phenyl ring alongside a trifluoroacetyl group, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic electronic materials due to its ability to modify electronic properties.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1-(2-Chloro-4-Fluoro-Phenyl)-2,2,2-Trifluoro-Ethanone
CAS No.	886370-93-0
Molecular Formula	C8H3ClF4O
Molecular Weight	226.56 g/mol
Synonyms	2-Chloro-4-fluoro-α,α,α-trifluoroacetophenone; 2'-Chloro-4'-fluoro-2,2,2-trifluoroacetophenone; 1-(2-Chloro-4-fluorophenyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(2-chloro-4-fluorophenyl)ethanone; α,α,α-Trifluoro-2-chloro-4-fluoroacetophenone; CF3CO(2-Cl-4-F-C6H3); TFAP derivative
EINECS	Contact for details

Quality Control

Our 1-(2-Chloro-4-Fluoro-Phenyl)-2,2,2-Trifluoro-Ethanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and consistent lot-to-lot performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.