Description

2,2,2-Trifluoro-1-(6-Methoxy-Naphthalen-2-Yl)-Ethanone is a high-value trifluoromethyl ketone derivative, a key structural motif prized for its unique electronic and steric properties. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry. It is essential for research and production in pharmaceutical development, particularly for creating novel active ingredients, and in agrochemical and material science applications where the introduction of fluorine atoms is required.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Fluorine Chemistry Research: An important reagent for studying fluorination reactions and the effects of fluorine substitution on molecular properties in academic and industrial R&D.
• Ligand and Catalyst Development: Utilized in the design and synthesis of novel chiral ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	2,2,2-Trifluoro-1-(6-Methoxy-Naphthalen-2-Yl)-Ethanone
CAS No.	886370-42-9
Molecular Formula	C₁₃H₉F₃O₂
Molecular Weight	254.21 g/mol
Synonyms	1-(6-Methoxy-2-naphthyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(6-methoxynaphthalen-2-yl)ethan-1-one; 6-Methoxy-2-naphthyl trifluoromethyl ketone; 2-Acetyl-6-methoxynaphthalene, 2,2,2-trifluoro derivative; 2',6'-Dimethoxy-2,2,2-trifluoroacetophenone (related naphthalene analog); TFMNK (abbreviation); 886370-42-9; 2-(Trifluoroacetyl)-6-methoxynaphthalene
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(6-Methoxy-Naphthalen-2-Yl)-Ethanone is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and industrial synthesis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality management system is designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to prevent degradation. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.