Description

2'-Methyl-2,2,2,5'-Tetrafluoroacetophenone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where the introduction of fluorine atoms is crucial for modulating biological activity and metabolic stability. It is primarily needed by research chemists and process development scientists working on novel active ingredients, including potential pharmaceuticals, crop protection agents, and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of fluorinated drug candidates, especially in central nervous system (CNS) and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where fluorine substitution enhances efficacy and environmental profile.
• Advanced Material Precursor: Serves as a monomer or modifier in the creation of specialty polymers and liquid crystals with unique optical or electronic properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions and as a substrate for introducing the trifluoromethylacetyl moiety into complex molecular architectures.
• Chemical Research & Development: A valuable tool for medicinal chemistry and process chemistry teams exploring structure-activity relationships (SAR) in fluorinated compounds.

Basic Information

Product Name	2'-Methyl-2,2,2,5'-Tetrafluoroacetophenone
CAS No.	886369-93-3
Molecular Formula	C9H6F4O
Molecular Weight	206.14 g/mol
Synonyms	1-(2-Methyl-5-fluorophenyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(2-methyl-5-fluorophenyl)ethanone; 2-Methyl-α,α,α,5-tetrafluoroacetophenone; 2'-Methyl-α,α,α,5'-tetrafluoroacetophenone; 1-(2-Methyl-5-fluorophenyl)-2,2,2-trifluoro-1-ethanone; 2-Methyl-2,2,2,5-tetrafluoroacetophenone
EINECS	Contact for details

Quality Control

Our 2'-Methyl-2,2,2,5'-Tetrafluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.