Description

2,2,2,3',4',5'-Hexafluoroacetophenone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals, agrochemicals, and specialty materials, where the introduction of fluorine atoms is critical for modulating biological activity, stability, and physical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex, value-added molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing fluorinated active pharmaceutical ingredients (APIs), particularly in CNS and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where fluorine substitution enhances efficacy and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, nucleophilic additions, and as a precursor for other fluorinated synthons in complex organic transformations.
• Chemical Research & Development: A valuable tool for academic and industrial research exploring new fluorination methodologies and structure-activity relationships.

Basic Information

Product Name	2,2,2,3',4',5'-Hexafluoroacetophenone
CAS No.	886369-68-2
Molecular Formula	C8H2F6O
Molecular Weight	228.09 g/mol
Synonyms	1-(2,3,4-Trifluorophenyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(2,3,4-trifluorophenyl)ethanone; Hexafluoroacetophenone (unspecified isomer); α,α,α,2,3,4-Hexafluoroacetophenone; 2,3,4-Trifluorophenyl trifluoromethyl ketone; TFAP (context-specific abbreviation); Perfluoroacetophenone derivative
EINECS	Contact for details

Quality Control

Our 2,2,2,3',4',5'-Hexafluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We can support development and production needs across various purity grades, from research (≥97%) to high-purity (≥99%) standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container must be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Research Grade)
Purity (HPLC/GC)	≥99.0% (High Purity Grade)
Water Content (KF)	≤0.5%
Related Substances (HPLC)	≤2.0% total

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.