Description

2,2,2-Trifluoro-1-(4-Isopropyl-Phenyl)-Ethylamine is a specialized fluorinated aromatic amine building block of significant interest in advanced organic synthesis. Its unique structure, featuring a trifluoroethylamine moiety attached to an isopropylbenzene core, makes it a valuable intermediate for creating novel compounds with tailored properties. This high-purity chemical is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries. It serves as a critical precursor in the development of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms can enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science: Incorporated into the synthesis of specialty polymers, liquid crystals, and advanced organic electronic materials to modify thermal and electronic properties.
• Fluorine Chemistry Research: An essential reagent for studying structure-activity relationships (SAR) and introducing the trifluoroethyl pharmacophore into molecular scaffolds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Item	Details
Product Name	2,2,2-Trifluoro-1-(4-Isopropyl-Phenyl)-Ethylamine
CAS No.	886369-16-0
Molecular Formula	C11H14F3N
Molecular Weight	217.23 g/mol
Synonyms	α-(Trifluoromethyl)-4-isopropylbenzeneethanamine; 1-(4-Isopropylphenyl)-2,2,2-trifluoroethanamine; 4-Isopropyl-α-(trifluoromethyl)benzeneethanamine; 2,2,2-Trifluoro-1-(4-propan-2-ylphenyl)ethan-1-amine; 1-(4-Isopropylphenyl)-2,2,2-trifluoroethylamine; TFIPEA; (4-Isopropylphenyl)(trifluoromethyl)methylamine
EINECS	Contact for details

Quality Control

Every batch of 2,2,2-Trifluoro-1-(4-Isopropyl-Phenyl)-Ethylamine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent lot-to-lot performance. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with each shipment and are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong acids and strong oxidizing agents. Due to its fluoride/strong alkali-related properties, appropriate chemical handling procedures should be followed.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.