Description

1-(4-Bromopyridin-2-Yl)-2,2,2-Trifluoroethanone is a high-purity brominated and fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a bromo-substituent and a trifluoroacetyl group, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the bromopyridine and trifluoromethyl motifs can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands in transition metal catalysis and organocatalysis, enabling more efficient and selective chemical transformations.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or fluorinated polymers, due to its electron-deficient aromatic system.
• Custom Synthesis and Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	1-(4-Bromopyridin-2-Yl)-2,2,2-Trifluoroethanone
CAS No.	886364-53-0
Molecular Formula	C7H3BrF3NO
Molecular Weight	253.00 g/mol
Synonyms	2,2,2-Trifluoro-1-(4-bromo-2-pyridinyl)ethanone; 1-(4-Bromo-2-pyridinyl)-2,2,2-trifluoroethanone; 4-Bromo-2-(trifluoroacetyl)pyridine; 4-Bromo-2-pyridyl trifluoromethyl ketone; 2-(Trifluoroacetyl)-4-bromopyridine; 4-Bromo-α,α,α-trifluoro-2-pyridinemethanol ketone; 886364-53-0
EINECS	Contact for details

Quality Control

Our 1-(4-Bromopyridin-2-Yl)-2,2,2-Trifluoroethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.