Description

1-(6-Bromo-Pyridin-3-Yl)-2,2,2-Trifluoro-Ethanone is a high-purity brominated pyridine derivative and a versatile trifluoromethyl ketone building block. This compound is critical for introducing the 6-bromopyridin-3-yl moiety and the reactive trifluoroacetyl group into complex molecular architectures. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the biological activity of the pyridine and trifluoromethyl motifs.
• Material Science Research: Serves as a building block for creating specialized ligands, catalysts, and organic frameworks used in catalysis and advanced materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form biaryl structures.
• Fluorinated Compound Library: Essential for medicinal chemistry programs focused on building fluorinated compound libraries to study metabolic stability and bioavailability.
• Chemical Biology Probes: Utilized in the development of chemical probes and inhibitors for studying enzyme function and biological pathways.

Basic Information

Product Name	1-(6-Bromo-Pyridin-3-Yl)-2,2,2-Trifluoro-Ethanone
CAS No.	886364-47-2
Molecular Formula	C7H3BrF3NO
Molecular Weight	253.00 g/mol
Synonyms	6-Bromo-3-pyridyl trifluoromethyl ketone; 1-(6-Bromopyridin-3-yl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(6-bromo-3-pyridinyl)ethanone; 6-Bromo-3-trifluoroacetylpyridine; 3-Acetyl-6-bromopyridine, 2,2,2-trifluoro-; 1-(6-Bromo-3-pyridyl)-2,2,2-trifluoroethanone; (6-Bromopyridin-3-yl)(trifluoromethyl)methanone
EINECS	Contact for details

Quality Control

Our 1-(6-Bromo-Pyridin-3-Yl)-2,2,2-Trifluoro-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material is suitable for demanding applications in research and scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.