Description

2'-Trifluoromethoxyphenyl Acetylene is a high-purity, specialized aromatic acetylene derivative featuring a trifluoromethoxy substituent, making it a valuable synthon for advanced organic synthesis. This compound is essential for introducing the unique trifluoromethoxyphenyl moiety into target molecules, which can significantly alter their electronic properties, lipophilicity, and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology, where the trifluoromethoxy group is a privileged pharmacophore.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the enhanced biological activity and environmental persistence imparted by the fluorine-containing group.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, liquid crystals, and organic electronic materials due to its rigid, conjugated structure and unique electronic properties.
• Cross-Coupling Reactions: An excellent substrate for Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to create extended conjugated systems or complex biaryl structures.
• Click Chemistry: Utilized in Huisgen 1,3-dipolar cycloaddition (copper-catalyzed azide-alkyne cycloaddition) for bioconjugation, polymer modification, and library synthesis in drug discovery.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for methodological studies and the exploration of new synthetic pathways involving functionalized acetylenes.

Basic Information

Product Name	2'-Trifluoromethoxyphenyl Acetylene
CAS No.	886363-40-2
Molecular Formula	C9H5F3O
Molecular Weight	186.13 g/mol
Synonyms	2-(Trifluoromethoxy)phenylacetylene; 1-Ethynyl-2-(trifluoromethoxy)benzene; 2-Ethynyl-1-(trifluoromethoxy)benzene; o-(Trifluoromethoxy)phenylacetylene; (2-(Trifluoromethoxy)phenyl)ethyne; 2-Trifluoromethoxyphenylacetylene; 2'-Trifluoromethoxy phenylacetylene
EINECS	Contact for details

Quality Control

Our 2'-Trifluoromethoxyphenyl Acetylene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, open flames, and oxidizing agents. For long-term storage, consider storing under an inert atmosphere (e.g., nitrogen or argon) to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.