Description

3-Methylthiophene-2-Boronic Acid Pinacol Ester is a high-purity organoboron reagent, specifically a protected boronic acid derivative, essential for modern synthetic chemistry. Its primary value lies in enabling efficient and selective cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecules. This compound is a critical building block for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to introduce the 3-methylthiophene moiety into target structures.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), particularly in the development of novel heterocyclic compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides that require specific thiophene-based architectures.
• Material Science Research: Serves as a precursor in the development of organic electronic materials, such as conductive polymers and organic light-emitting diodes (OLEDs).
• Suzuki-Miyaura Cross-Coupling: The primary application, facilitating carbon-carbon bond formation between aryl/heteroaryl halides and this boronic ester under palladium catalysis.
• Ligand and Catalyst Development: Employed in the synthesis of novel ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Used to create tagged molecules for studying biological processes and protein interactions.

Basic Information

Product Name	3-Methylthiophene-2-Boronic Acid Pinacol Ester
CAS No.	885692-91-1
Molecular Formula	C11H17BO2S
Molecular Weight	224.13 g/mol
Synonyms	2-(3-Methylthiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Methyl-2-thienylboronic Acid Pinacol Ester; 2-(3-Methyl-2-thienyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Methylthiophene-2-Boronic Acid Pinanediol Ester (common alternate); Pinacol (3-Methyl-2-thienyl)boronate; 3-Methyl-2-thiopheneboronic Acid Pinacol Ester; B-(3-Methyl-2-thienyl)boronic Acid Pinacol Ester
EINECS	Contact for details

Quality Control

Our 3-Methylthiophene-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.