Description

1-(2,3-Difluoro-4-Iodophenyl)Ethanone is a high-purity fluorinated and iodinated aromatic ketone building block. This compound is critical for advanced organic synthesis, particularly in the development of novel pharmaceuticals and agrochemicals where its unique halogenated structure enables precise molecular modifications. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating complex active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and pesticides, leveraging the bioactivity of fluorine and iodine substituents.
• Material Science Precursor: Serves as a building block for synthesizing specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine moiety makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct complex biaryl systems.
• Chemical Synthesis: Utilized in nucleophilic substitution and carbonyl chemistry to introduce the difluoro-iodophenyl moiety into target molecules.
• R&D and Process Chemistry: Essential for medicinal chemistry programs and scale-up process optimization in contract research and manufacturing organizations (CROs/CMOs).

Basic Information

Product Name	1-(2,3-Difluoro-4-Iodophenyl)Ethanone
CAS No.	885590-86-3
Molecular Formula	C8H5F2IO
Molecular Weight	282.03 g/mol
Synonyms	2',3'-Difluoro-4'-iodoacetophenone; 1-Acetyl-2,3-difluoro-4-iodobenzene; 4'-Iodo-2',3'-difluoroacetophenone; Ethanone, 1-(2,3-difluoro-4-iodophenyl)-; 2,3-Difluoro-4-iodoacetophenone; (2,3-Difluoro-4-iodophenyl)ethan-1-one
EINECS	Contact for details

Quality Control

Every batch of 1-(2,3-Difluoro-4-Iodophenyl)Ethanone is manufactured and tested under strict quality management systems. We guarantee high chemical purity and consistency, supported by comprehensive analytical documentation. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles as per client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider keeping under an inert atmosphere (e.g., nitrogen or argon) to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.