Description

4-Fluoro-6-Indazolecarboxylic Acid Methyl Ester is a high-value fluorinated indazole derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in providing a functionalized scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine and ester functionalities into heterocyclic systems.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides with enhanced activity and selectivity.
• Chemical Biology Probes: Serves as a precursor for fluorescent tags or activity-based probes used in biochemical assays and diagnostic research.
• Material Science: Potential monomer or precursor for specialty polymers and advanced organic electronic materials.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and exploratory synthesis projects.
• Custom Synthesis: Starting material for the contract manufacturing of specific, high-value target molecules for client projects.

Basic Information

Product Name	4-Fluoro-6-Indazolecarboxylic Acid Methyl Ester
CAS No.	885521-44-8
Molecular Formula	C9H7FN2O2
Molecular Weight	194.16 g/mol
Synonyms	Methyl 4-Fluoro-1H-indazole-6-carboxylate; 4-Fluoro-1H-indazole-6-carboxylic acid methyl ester; 6-(Methoxycarbonyl)-4-fluoro-1H-indazole; 4-Fluoro-6-carbomethoxyindazole; 4-Fluoroindazole-6-carboxylic Acid Methyl Ester; 885521-44-8; Methyl 4-fluoro-6-indazolecarboxylate
EINECS	Contact for details

Quality Control

Our 4-Fluoro-6-Indazolecarboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with key parameters including assay by HPLC, impurity profile, and confirmation of structure. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.