Description

4-Iodo-3-Hydroxy-6-Nitroindazole is a specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines an indazole core with strategically placed iodine, nitro, and hydroxyl functional groups, enabling precise chemical modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of targeted drug candidates, particularly those exploring kinase inhibition or other heterocycle-dependent mechanisms of action.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or plant growth regulators that leverage its nitroindazole structure.
• Chemical Biology Probe: Acts as a versatile scaffold for creating molecular probes to study enzyme function and biological pathways due to its modifiable sites.
• Material Science Research: Investigated as a building block for advanced organic materials, such as ligands for metal-organic frameworks (MOFs) or components in specialty polymers.
• Cross-Coupling Reactions: The iodine substituent makes it a valuable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create more complex biaryl structures.
• Academic & Institutional R&D: Employed in university and research institute laboratories for methodological studies in heterocyclic and organoiodine chemistry.

Basic Information

Product Name	4-Iodo-3-Hydroxy-6-Nitroindazole
CAS No.	885519-96-0
Molecular Formula	C7H4IN3O3
Molecular Weight	304.99 g/mol
Synonyms	6-Nitro-4-iodo-1H-indazol-3-ol; 4-Iodo-6-nitro-1H-indazol-3-ol; 3-Hydroxy-4-iodo-6-nitroindazole; 4-Iodo-3-hydroxy-6-nitro-1H-indazole; 1H-Indazol-3-ol, 4-iodo-6-nitro-; 885519-96-0; 4-Iodo-6-nitroindazol-3-ol
EINECS	Contact for details

Quality Control

Our 4-Iodo-3-Hydroxy-6-Nitroindazole is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR), to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its light-sensitive nature, the container should be opaque or kept in dark conditions. Keep away from strong oxidizers and incompatible materials. For long-term storage, consider under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Yellow to brown powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0 %
Residue on Ignition	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.