Description

5-Fluoro-2,3-Dihydro-Benzofuran-3-Ylamine Hydrochloride is a high-purity, pharmaceutically relevant building block used in the synthesis of novel active compounds. Its value lies in its role as a versatile chiral amine intermediate, enabling the development of targeted drug candidates with specific biological activity. This compound is essential for research and development chemists in the pharmaceutical and biotechnology industries, particularly those working on central nervous system (CNS) agents, enzyme inhibitors, and other therapeutic small molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• CNS Drug Development: Serves as a building block for potential therapeutics targeting neurological and psychiatric disorders.
• Enzyme Inhibitor Synthesis: Incorporated into molecules designed to modulate specific enzymatic pathways.
• Preclinical & Process Chemistry: Employed in scaling up synthetic routes from milligram to kilogram scale for preclinical and clinical trial material.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized compounds.

Basic Information

Product Name	5-Fluoro-2,3-Dihydro-Benzofuran-3-Ylamine Hydrochloride
CAS No.	885280-83-1
Molecular Formula	C8H9ClFNO
Molecular Weight	189.61 g/mol
Synonyms	5-Fluoro-2,3-dihydro-3-benzofuranamine hydrochloride; 3-Amino-5-fluoro-2,3-dihydrobenzofuran hydrochloride; 5-Fluoro-2,3-dihydrobenzofuran-3-amine HCl; 5-Fluoro-3-amino-2,3-dihydrobenzofuran hydrochloride; (3-Amino-5-fluoro-2,3-dihydrobenzofuran) hydrochloride; 885280-83-1; 5-Fluoro-2,3-dihydro-1-benzofuran-3-amine hydrochloride
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2,3-Dihydro-Benzofuran-3-Ylamine Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.