Description

Ethyl 2,2-Dimethyl-4,4,4-Trifluorobutyrate is a high-value fluorinated ester building block prized for its unique trifluoromethyl group, which imparts desirable properties like enhanced metabolic stability and lipophilicity to target molecules. This compound is essential for research and development chemists seeking to introduce fluorine motifs into complex organic structures. It is primarily utilized in the synthesis of advanced pharmaceutical intermediates and agrochemicals, serving the needs of the life sciences and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of active pharmaceutical ingredients (APIs) containing trifluoromethylated motifs, which are prevalent in modern drug discovery.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the CF3 group enhances biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for fluorinated monomers or additives to modify polymer properties such as solvent resistance and surface energy.
• Liquid Crystal & OLED Materials: Employed in the synthesis of fluorinated components for electronic display technologies.
• Organic Synthesis Building Block: Utilized in various carbon-carbon bond formation reactions, including alkylations and Reformatsky-type reactions, to construct complex fluorinated molecules.

Basic Information

Product Name	Ethyl 2,2-Dimethyl-4,4,4-Trifluorobutyrate
CAS No.	885275-92-3
Molecular Formula	C8H13F3O2
Molecular Weight	198.18 g/mol
Synonyms	4,4,4-Trifluoro-2,2-dimethylbutyric Acid Ethyl Ester; Ethyl 4,4,4-Trifluoro-2,2-dimethylbutanoate; 2,2-Dimethyl-4,4,4-trifluorobutanoic Acid Ethyl Ester; Butanoic acid, 4,4,4-trifluoro-2,2-dimethyl-, ethyl ester; Ethyl α,α-dimethyl-β,β,β-trifluorobutyrate
EINECS	Contact for details

Quality Control

Our production of Ethyl 2,2-Dimethyl-4,4,4-Trifluorobutyrate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is fully characterized and tested. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.