Description

8-Bromo-2H-chromene-3-carbonitrile is a versatile brominated heterocyclic building block of significant interest in advanced organic synthesis. Its core structure, featuring both a bromine atom and a nitrile group on a chromene scaffold, makes it a valuable precursor for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel drug candidates, particularly for creating libraries of chromene and fused heterocyclic derivatives.
• Agrochemical Synthesis: Used in the synthesis of advanced crop protection agents and pesticides, leveraging its reactive bromine and nitrile functionalities.
• Material Science Research: Acts as a monomer or precursor for the development of organic electronic materials, dyes, and photoresponsive polymers.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and enzyme functions.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form new carbon-carbon bonds.
• Nitrile Transformation Chemistry: The cyano group can be hydrolyzed to carboxylic acids, reduced to amines, or used in cycloaddition reactions to form heterocycles like tetrazoles.

Basic Information

Product Name	8-Bromo-2H-chromene-3-carbonitrile
CAS No.	885270-76-8
Molecular Formula	C10H6BrNO
Molecular Weight	236.07 g/mol
Synonyms	8-Bromo-2H-1-benzopyran-3-carbonitrile; 8-Bromo-3-cyano-2H-chromene; 8-Bromo-3-cyano-2H-1-benzopyran; 3-Cyano-8-bromo-2H-chromene; 8-Bromo-2H-chromene-3-carbonitrile; 885270-76-8; 8-Bromochromene-3-carbonitrile
EINECS	Contact for details

Quality Control

Our 8-Bromo-2H-chromene-3-carbonitrile is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and GC-MS for impurity profiling. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.