Description

1-Bromo-3-(2,2-Difluoro-Ethylsulfanyl)-Benzene is a specialized organosulfur and organobromine compound, serving as a high-value building block in advanced synthetic chemistry. Its unique structure, featuring both a bromine substituent and a difluoroethylthioether group, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of molecules containing sulfur and fluorine motifs for enhanced bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoroethylthioether group can contribute to improved lipophilicity and target binding.
• Material Science Research: Serves as a precursor for novel monomers or ligands in the development of specialty polymers, liquid crystals, or organic electronic materials.
• Cross-Coupling Reactions: The aryl bromide moiety makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl and conjugated systems.
• Chemical Biology Probes: Utilized in the design and synthesis of chemical probes for studying enzyme mechanisms or protein-ligand interactions, leveraging the reactivity of the bromine and sulfur groups.

Basic Information

Item	Detail
Product Name	1-Bromo-3-(2,2-Difluoro-Ethylsulfanyl)-Benzene
CAS No.	885267-08-3
Molecular Formula	C8H7BrF2S
Molecular Weight	253.11 g/mol
Synonyms	3-Bromo-1-(2,2-difluoroethylthio)benzene; 1-Bromo-3-((2,2-difluoroethyl)thio)benzene; 3-((2,2-Difluoroethyl)thio)bromobenzene; m-Bromo(2,2-difluoroethylthio)benzene; Benzene, 1-bromo-3-[(2,2-difluoroethyl)thio]-; (2,2-Difluoroethyl)(3-bromophenyl) sulfide
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-(2,2-Difluoro-Ethylsulfanyl)-Benzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming identity, purity, and impurity profiles to meet your specific R&D or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Handle and store under an inert atmosphere if prolonged storage is required to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.