Description

n-(6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzo[D]Thiazol-2-Yl)Acetamide is a high-purity, advanced pharmaceutical intermediate featuring a benzothiazole core and a protected boronic ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone technology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutic agents, particularly in oncology and CNS disease research.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to create diverse compound libraries for biological screening.
• Suzuki-Miyaura Cross-Coupling Reagent: The pinacol boronate ester moiety serves as a stable, reactive handle for palladium-catalyzed carbon-carbon bond formation with aryl halides.
• Chemical Biology Probe Development: Incorporated into molecular probes to study protein function and enzyme activity within biological systems.
• Material Science Research: Potential precursor for the synthesis of organic electronic materials and ligands for catalytic systems.

Basic Information

Product Name	n-(6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzo[D]Thiazol-2-Yl)Acetamide
CAS No.	885069-14-7
Molecular Formula	C₁₅H₁₉BN₂O₃S
Molecular Weight	318.20 g/mol
Synonyms	2-Acetamido-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzothiazole; N-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzothiazol-2-yl]acetamide; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-acetamidobenzothiazole; Acetamide, N-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-benzothiazolyl]-; Benzothiazole, 2-acetamido-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; BTR-2-Acetamide Boronate Ester
EINECS	Contact for details

Quality Control

Our n-(6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzo[D]Thiazol-2-Yl)Acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.