Description

2-(3-Bromophenyl)-2,2-Difluoroacetic Acid is a high-value, multi-functional fluorinated building block essential for advanced organic synthesis. This compound is particularly significant for its role in introducing the difluoroacetate moiety into complex molecular architectures, enabling the fine-tuning of physicochemical properties. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring fluorinated motifs to enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the difluoroacetic acid group can improve efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or modifier in the synthesis of specialty polymers and advanced materials with unique surface properties.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new C-F bond formation reactions and the synthesis of complex fluorinated molecules.
• Diagnostic Agent Synthesis: Potential intermediate in the production of fluorinated contrast agents or radiotracers for medical imaging (e.g., PET).

Basic Information

Product Name	2-(3-Bromophenyl)-2,2-Difluoroacetic Acid
CAS No.	885068-76-8
Molecular Formula	C8H5BrF2O2
Molecular Weight	251.03 g/mol
Synonyms	α,α-Difluoro-3-bromophenylacetic Acid; 2,2-Difluoro-2-(3-bromophenyl)acetic Acid; 3-Bromo-α,α-difluorobenzeneacetic Acid; (3-Bromophenyl)difluoroacetic Acid; 2-(3-Bromophenyl)-2,2-difluoroethanoic Acid; Difluoro(3-bromophenyl)acetic Acid
EINECS	Contact for details

Quality Control

Every batch of 2-(3-Bromophenyl)-2,2-Difluoroacetic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical R&D and scale-up processes. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), identity (NMR, IR), and impurity profiles are available upon request and can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.