Description

1-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl]Pyrrolidine is a high-value, organoboron building block essential for modern synthetic chemistry. This compound is a protected boronic acid derivative, offering superior stability and handling characteristics compared to its free acid form, which is critical for reliable cross-coupling reactions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl/heteroaryl halides and the boronate ester moiety, enabling the synthesis of biaryl structures prevalent in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Serves as a critical building block in the multi-step synthesis of drug candidates, particularly in oncology, CNS, and antiviral research pipelines.
• Agrochemical Development: Used to create novel herbicides, fungicides, and insecticides by introducing the benzylpyrrolidine-boronate functional group into lead structures.
• Material Science & OLED Research: Employed in the synthesis of organic semiconductors, light-emitting materials, and other functional organic molecules for electronic applications.
• Medicinal Chemistry & Library Synthesis: Facilitates rapid parallel and combinatorial synthesis for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Scale-up Process Chemistry: Its stability makes it suitable for transitioning from milligram-scale discovery to kilogram-scale pilot plant and commercial manufacturing.

Basic Information

Product Name	1-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl]Pyrrolidine
CAS No.	884507-45-3
Molecular Formula	C17H26BNO2
Molecular Weight	287.21 g/mol
Synonyms	3-((Pyrrolidin-1-yl)methyl)phenylboronic acid pinacol ester; 1-((3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl)pyrrolidine; (3-(Pyrrolidin-1-ylmethyl)phenyl)boronic acid pinacol ester; 3-(Pyrrolidin-1-ylmethyl)benzeneboronic acid pinacol ester; 1-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]pyrrolidine; N-((3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our production of 1-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl]Pyrrolidine adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity (typically ≥97%), NMR (1H, 13C, 11B) for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Recommended long-term storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.