Description

1-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole is a high-value, synthetically versatile boronic ester derivative, serving as a critical building block in modern organic synthesis. Its primary value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for indole-based drug candidates targeting central nervous system disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific indole-boronate motifs.
• Material Science: Building block for creating organic semiconductors, light-emitting diodes (OLEDs), and other functional materials where precise molecular engineering is required.
• Chemical Biology & Proteomics: Employed in the development of molecular probes, enzyme inhibitors, and bioconjugation reagents for target identification and validation.
• Academic & Contract Research: Fundamental reagent for methodology development in cross-coupling chemistry and the exploration of new synthetic pathways in university and CRO laboratories.
• Scale-up Process Chemistry: Suitable for process optimization and pilot-scale synthesis, providing a reliable route to larger quantities of target molecules.

Basic Information

Product Name	1-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole
CAS No.	884507-19-1
Molecular Formula	C15H20BNO2
Molecular Weight	257.14 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1H-indole; 1-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole; 1-Methyl-1H-indole-6-boronic acid pinacol ester; 6-Borono-1-methylindole pinacol ester; 1-Methyl-6-indoleboronic acid pinacol ester; 6-(1,3,2-Dioxaborinan-2-yl)-1-methyl-1H-indole (pinacol ester); 884507-19-1 (CAS Index Name)
EINECS	Contact for details

Quality Control

Our 1-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.