Description

Bis-3',5'-Trifluoromethyl-3-(1,3-Dioxan-2-Yl)-Propiophenone is a high-value, specialized organic intermediate featuring a unique trifluoromethylated aromatic core protected by a dioxane moiety. This compound matters for its role as a critical building block in the synthesis of advanced pharmaceutical and agrochemical active ingredients, where its structure imparts desirable metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries seeking to develop novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Serves as a crucial building block for developing new-generation herbicides, fungicides, and insecticides that leverage the properties of the trifluoromethyl group.
• Material Science Research: Used in the development of specialty polymers and advanced organic materials with tailored electronic or surface properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry for creating novel ligands and catalysts used in asymmetric synthesis and cross-coupling reactions.
• Fluorine Chemistry Studies: An important compound for academic and industrial research focused on the synthesis and reactivity of complex fluorinated molecules.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific synthesis projects.

Basic Information

Product Name	Bis-3',5'-Trifluoromethyl-3-(1,3-Dioxan-2-Yl)-Propiophenone
CAS No.	884504-38-5
Molecular Formula	C₁₇H₁₆F₆O₃
Molecular Weight	406.30 g/mol
Synonyms	3,5-Bis(trifluoromethyl)-3-(1,3-dioxan-2-yl)propiophenone; 2-[3,5-Bis(trifluoromethyl)phenyl]-1-(1,3-dioxan-2-yl)ethan-1-one; 1-[3,5-Bis(trifluoromethyl)phenyl]-3-(1,3-dioxan-2-yl)propan-1-one; Bis(3,5-trifluoromethyl)-3-(1,3-dioxan-2-yl)propiophenone; 884504-38-5; Propiophenone, 3',5'-bis(trifluoromethyl)-3-(1,3-dioxan-2-yl)-
EINECS	Contact for details

Quality Control

Our Bis-3',5'-Trifluoromethyl-3-(1,3-Dioxan-2-Yl)-Propiophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.