Description

2-Cyano-3-(Trifluoromethyl)Phenyl Boronic Acid Neopentyl Glycol Ester is a high-value, advanced pharmaceutical intermediate and building block for organic synthesis. This compound is critical for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, particularly through Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce a functionalized, trifluoromethylated aromatic moiety into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for palladium-catalyzed carbon-carbon bond formation to construct biaryl systems.
• Ligand and Catalyst Development: Employed in the research and production of specialized ligands for catalysis and material science.
• Organic Electronic Materials: A precursor in the synthesis of functional molecules for OLEDs, semiconductors, and other electronic applications.
• Chemical Research & Development: A valuable tool for medicinal and process chemistry in both academic and industrial laboratories.

Basic Information

Product Name	2-Cyano-3-(Trifluoromethyl)Phenyl Boronic Acid Neopentyl Glycol Ester
CAS No.	883899-03-4
Molecular Formula	C15H15BF3NO2
Molecular Weight	309.09 g/mol
Synonyms	[2-Cyano-3-(trifluoromethyl)phenyl]boronic acid neopentyl glycol ester; 2-(2-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane; 2-Cyano-3-(trifluoromethyl)benzeneboronic acid neopentyl glycol ester; Boronic acid, B-[2-cyano-3-(trifluoromethyl)phenyl]-, 2,2-dimethyl-1,3-propanediyl ester; (2-Cyano-3-(trifluoromethyl)phenyl)boronic acid pinacol ester (common analog); CAS 883899-03-4; Trifluoromethylated cyanophenyl boronic ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for high-purity intermediates. Each batch is characterized by advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request. We adhere to a quality management system to support our customers' needs for reliable and traceable materials in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep away from incompatible materials such as strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.