Description

2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-5-(trifluoromethyl)benzonitrile is a high-value, multifunctional boronic ester derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly Suzuki-Miyaura couplings, to construct complex molecular architectures with precision. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-purity building blocks for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing trifluoromethyl and nitrile functional groups.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides where the boronic ester moiety facilitates the introduction of complex aryl groups.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where its structure allows for fine-tuning of electronic properties.
• Cross-Coupling Reactions: A versatile reagent for Suzuki-Miyaura coupling, a cornerstone reaction for forming carbon-carbon bonds in complex molecule assembly.
• Chemical Biology & Probe Development: Useful for creating molecular probes and labeled compounds for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs as a specialized starting material for client-directed synthesis projects.

Basic Information

Product Name	2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-5-(trifluoromethyl)benzonitrile
CAS No.	883898-98-4
Molecular Formula	C14H15BF3NO2
Molecular Weight	297.08 g/mol
Synonyms	5-(Trifluoromethyl)-2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile; 2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-5-(trifluoromethyl)benzonitrile; 5-Cyano-2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzotrifluoride; Pinacol [5-Cyano-2-(trifluoromethyl)phenyl]boronate; (5-Cyano-2-(trifluoromethyl)phenyl)boronic acid pinacol ester; 2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-α,α,α-trifluoro-p-tolunitrile
EINECS	Contact for details

Quality Control

Our 2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-5-(trifluoromethyl)benzonitrile is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry-standard analytical methods, and specifications can be tailored to meet specific project requirements, including custom purity grades.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.