Description

2-Cyano-6-Methoxyphenyl Boronic Acid Neopentyl Glycol Ester is a high-purity, protected boronic acid derivative, specifically designed as a key synthetic intermediate. Its primary value lies in its enhanced stability and reactivity profile compared to its free boronic acid counterpart, making it a superior reagent for sensitive cross-coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block in Suzuki-Miyaura cross-couplings for constructing complex biaryl scaffolds found in drug candidates.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides requiring specific aryl-aryl linkages.
• Material Science Research: Serves as a monomer or precursor in the synthesis of organic electronic materials, such as polymers for OLEDs.
• Chemical Biology: Employed in the synthesis of probes and ligands where the protected boronate ester offers improved handling and stability.
• Process Chemistry: Preferred in large-scale manufacturing due to its neopentyl glycol protection, which minimizes protodeboronation and improves yield.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for clients.

Basic Information

Product Name	2-Cyano-6-Methoxyphenyl Boronic Acid Neopentyl Glycol Ester
CAS No.	883898-97-3
Molecular Formula	C15H20BNO4
Molecular Weight	289.14 g/mol
Synonyms	2-Methoxy-6-cyanophenylboronic acid neopentyl glycol ester; (6-Cyano-2-methoxyphenyl)boronic acid neopentyl glycol ester; 2-Cyano-6-methoxybenzeneboronic acid neopentyl glycol ester; B-(6-Cyano-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane? (Common pinacol ester analog); 2-Methoxy-6-cyanophenyl-B-neopentyl glycol boronate; Boronic ester of 2-cyano-6-methoxyphenylboronic acid; 883898-97-3 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 2-Cyano-6-Methoxyphenyl Boronic Acid Neopentyl Glycol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.