Description

5-Chloro-2-Cyanophenylboronic Acid Neopentyl Glycol Ester is a high-purity, protected boronic acid derivative essential for advanced organic synthesis. This compound matters as a critical building block in cross-coupling reactions, offering enhanced stability and handling characteristics compared to its free boronic acid counterpart. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides requiring specific biphenyl or heterobiaryl structures.
• Material Science Research: Serves as a monomer or building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized for labeling and modifying biomolecules in proteomics and diagnostic assay development.
• Academic & Industrial R&D: A versatile reagent for methodological development in synthetic organic chemistry laboratories worldwide.

Basic Information

Product Name	5-Chloro-2-Cyanophenylboronic Acid Neopentyl Glycol Ester
CAS No.	883898-93-9
Molecular Formula	C14H17BClNO3
Molecular Weight	293.55 g/mol
Synonyms	5-Chloro-2-cyanophenylboronic acid neopentyl glycol ester; (5-Chloro-2-cyanophenyl)boronic acid neopentyl ester; 2-Chloro-5-cyanophenylboronic acid neopentyl glycol ester; 5-Chloro-2-cyanobenzene-1-boronic acid neopentyl ester; B-(5-Chloro-2-cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Chloro-2-cyanophenyl MIDA boronate (related protected form); Boronic ester of 5-chloro-2-cyanobenzeneboronic acid; CAS 883898-93-9
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Cyanophenylboronic Acid Neopentyl Glycol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.