Description

2-Bromo-4-Trifluoromethoxy-1-Iodobenzene is a high-purity, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine, iodine, and a trifluoromethoxy group, makes it a versatile and valuable intermediate for constructing complex molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating complex aromatic cores via Suzuki, Stille, or other palladium-catalyzed cross-coupling reactions.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the trifluoromethoxy group can enhance biological activity and metabolic stability.
• Material Science: Serves as a precursor for synthesizing specialty monomers and ligands used in advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Synthesis: Employed in medicinal chemistry for lead optimization and structure-activity relationship (SAR) studies due to its orthogonal reactivity (Br vs. I).
• Fluorine Chemistry: The trifluoromethoxy moiety makes it a valuable substrate for studying the introduction and effects of fluorinated groups in molecular design.

Basic Information

Product Name	2-Bromo-4-Trifluoromethoxy-1-Iodobenzene
CAS No.	883546-30-3
Molecular Formula	C7H3BrF3IO
Molecular Weight	366.90 g/mol
Synonyms	1-Bromo-2-iodo-5-(trifluoromethoxy)benzene; 2-Bromo-1-iodo-4-(trifluoromethoxy)benzene; Benzene, 2-bromo-1-iodo-4-(trifluoromethoxy)-; 1-Iodo-2-bromo-4-(trifluoromethoxy)benzene; 4-Trifluoromethoxy-2-bromo-1-iodobenzene
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4-Trifluoromethoxy-1-Iodobenzene is manufactured and tested under strict quality management protocols to ensure consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for advanced chemical intermediates, ensuring traceability and compliance for regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.