Description

2-Chloro-6-Fluorocinnamaldehyde is a versatile fluorinated aromatic aldehyde building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents on the cinnamaldehyde backbone, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and photoactive polymers due to its electron-withdrawing substituents.
• Chemical Biology Probes: Utilized to build fluorescent tags and molecular probes for studying biological processes and enzyme mechanisms.
• Custom Synthesis and Contract Manufacturing: A valuable building block for custom chemical synthesis services catering to the fine chemical and life science industries.

Basic Information

Item	Details
Product Name	2-Chloro-6-Fluorocinnamaldehyde
CAS No.	883107-64-0
Molecular Formula	C9H6ClFO
Molecular Weight	184.59 g/mol
Synonyms	2-Chloro-6-fluorocinnamaldehyde; (2E)-3-(2-Chloro-6-fluorophenyl)prop-2-enal; (E)-3-(2-Chloro-6-fluorophenyl)acrylaldehyde; 2-Chloro-6-fluoro-cinnamaldehyde; trans-2-Chloro-6-fluorocinnamaldehyde; (E)-2-Chloro-6-fluorocinnamaldehyde; 3-(2-Chloro-6-fluorophenyl)-2-propenal
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-6-Fluorocinnamaldehyde is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with detailed impurity profiling available. Certificates of Analysis (COA) documenting all test results are provided with each shipment and are available upon request. We support development and scale-up projects with custom purity grades and analytical method development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere for long-term storage or when opening a new container. Keep away from strong oxidizing agents, strong bases, and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.